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Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

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PMC 4953733

These findings have not been replicated in human tissue or confirmed in prospective animal carcinogenicity studies using standardized ICH S1 protocols, which BPC-157 has never undergone

Somma D, Mastrovito P, Grieco M, Lavorgna A, Pignalosa A, Formisano L, et al